Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes
نویسندگان
چکیده
منابع مشابه
Nuclear pore complexes
What do they look like? A picture is worth twice the length of this article (Figure 1). All eukaryotes have these impressive structures: vertebrates have the Cadillac model (~125 MDa) and yeast a sportier version (~50 MDa). In spite of their immense size, these structures are made of a relatively small number of proteins — about 30 — the so-called nucleoporins or nups. Defining an NPC ‘interact...
متن کاملPerforating the nuclear boundary - how nuclear pore complexes assemble.
The nucleus is enclosed by the nuclear envelope, a double membrane which creates a selective barrier between the cytoplasm and the nuclear interior. Its barrier and transport characteristics are determined by nuclear pore complexes (NPCs) that are embedded within the nuclear envelope, and control molecular exchange between the cytoplasm and nucleoplasm. In this Commentary, we discuss the biogen...
متن کاملFormation and Distribution of Nuclear Pore Complexes in Interphase
The possibility of nuclear pore formation in the interphase nucleus was investigated in control and phytohemagglutinin (PHA) stimulated lymphocytes by the freeze-etching technique. 48 hr after the addition of PHA, the newly formed blasts which had not as yet divided had at least twice the number of pores per nucleus as controls. This clearly demonstrates that in lymphocytes nuclear pore formati...
متن کاملLamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement.
Mutations in LMNA, which encodes A-type lamins, result in disparate diseases, known collectively as laminopathies, that affect distinct tissues, including striated muscle and adipose tissue. Lamins provide structural support for the nucleus and sites of attachment for chromatin, and defects in these functions may contribute to disease pathogenesis. Recent studies suggest that A-type lamins may ...
متن کاملRecent Fukushima nuclear detonation, Chernobyl nuclear fallout, three mile island nuclear accident and atomic bomb explosion – rethinking the effects of nuclear radiations over human health
Background: The earlier Atomic Bomb explosion in Hiroshima and Nagasaki, and three worth mentioning nuclear accidents - detonation at Fukushima Daiichi nuclear plant, Chernobyl nuclear fallout and an accident at Three Mile Island nuclear power plant have made us more worried about the secure exploitation of nuclear energy. The central focus of this paper is to review radiation-mediated health e...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2020
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e19-01-0027